ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation

Petrus R. de Jong; Koji Taniguchi; Alexandra R. Harris; Samuel Bertin; Naoki Takahashi; Jen Duong; Alejandro D. Campos; Garth Powis; Maripat Corr; Michael Karin; Eyal Raz

doi:10.1038/ncomms11551

Nature Communications (May 2016)

ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation

Petrus R. de Jong,
Koji Taniguchi,
Alexandra R. Harris,
Samuel Bertin,
Naoki Takahashi,
Jen Duong,
Alejandro D. Campos,
Garth Powis,
Maripat Corr,
Michael Karin,
Eyal Raz

Affiliations

Petrus R. de Jong: Department of Medicine, University of California, San Diego
Koji Taniguchi: Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego
Alexandra R. Harris: Department of Medicine, University of California, San Diego
Samuel Bertin: Department of Medicine, University of California, San Diego
Naoki Takahashi: Department of Medicine, University of California, San Diego
Jen Duong: Department of Medicine, University of California, San Diego
Alejandro D. Campos: Sanford Burnham Prebys Medical Discovery Institute, NCI-Designated Cancer Center
Garth Powis: Sanford Burnham Prebys Medical Discovery Institute, NCI-Designated Cancer Center
Maripat Corr: Department of Medicine, University of California, San Diego
Michael Karin: Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego
Eyal Raz: Department of Medicine, University of California, San Diego

DOI: https://doi.org/10.1038/ncomms11551
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

Read online

It is unclear how the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathways interact with other signals in intestinal epithelial cells. Here, the authors show that upon loss of Erk1/2, or pharmacological inhibition of MEK1/2, the ERK5 pathway is upregulated to maintain epithelial cell proliferation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal