Nature Communications (Jun 2020)

Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

  • Renata M. Martin,
  • Jonas L. Fowler,
  • M. Kyle Cromer,
  • Benjamin J. Lesch,
  • Ezequiel Ponce,
  • Nobuko Uchida,
  • Toshinobu Nishimura,
  • Matthew H. Porteus,
  • Kyle M. Loh

DOI
https://doi.org/10.1038/s41467-020-16455-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.