Possible Role of Statins on the Inflammatory Biomarkers in Patients With Periodontal Disease: A Cross-Sectional Study

Abstract

Introduction: The aim of the present study was to demonstrate the possible role of statins on the inflammatory biomarkers in patients with periodontal disease (PD). Materials and Methods: This cross-sectional study involved 74 patients with PD and/or dyslipidemia divided into Group A: 34 patients with PD (nonstatins users); Group B: 40 patients with PD (statins users); and Group C: 30 healthy controls. Total cholesterol (TC), triglyceride (TG) and high-density lipoprotein, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and malondialdehyde (MDA) were measured . Blood pressure prolife and indices of PD were evaluated in each group. Statistical analysis was conducted by using SPSS version 20.0. Results: Inflammatory and lipid peroxidation biomarkers were higher in patients with PD compared with controls; IL-6, CRP, TNF-α, and MDA sera level were high in PD compared with controls (P = 0.001). Statins therapy led to significant reduction of TC, TG, very low and low-density lipoproteins, blood pressure profile, and cardiac risk indices with elevation in high-density lipoprotein compared with nonstatins users (P < 0.01). Statins therapy led to significant reduction in IL-6, CRP, TNF-α, and MDA sera levels compared with nonstatins users (P < 0.05). Conclusions: Statins therapy reduced PD-induced inflammatory changes in patients with chronic PD through reduction of inflammatory cytokines.

Keywords

• lipid peroxidation
• periodontal disease
• periodontal indices
• statins