An Alternative and Conserved Cell Wall Enzyme That Can Substitute for the Lipid II Synthase MurG

L. Zhang; K. Ramijan; V. J. Carrión; L. T. van der Aart; J. Willemse; G. P. van Wezel; D. Claessen

doi:10.1128/mBio.03381-20

mBio (Apr 2021)

An Alternative and Conserved Cell Wall Enzyme That Can Substitute for the Lipid II Synthase MurG

L. Zhang,
K. Ramijan,
V. J. Carrión,
L. T. van der Aart,
J. Willemse,
G. P. van Wezel,
D. Claessen

Affiliations

L. Zhang: Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands
K. Ramijan: Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands
V. J. Carrión: Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands
L. T. van der Aart: ORCiD; Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands
J. Willemse: Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands
G. P. van Wezel: ORCiD; Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands
D. Claessen: ORCiD; Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands

DOI: https://doi.org/10.1128/mBio.03381-20
Journal volume & issue: Vol. 12, no. 2

Abstract

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Almost all bacteria are surrounded by a cell wall, which protects cells from environmental harm. Formation of the cell wall requires the precursor molecule lipid II, which in bacteria is universally synthesized by the conserved and essential lipid II synthase MurG.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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