Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells

Abstract

Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.

Keywords

• tumor stem cell
• glioma stem cell
• malignant glioma
• glioblastoma
• treatment resistance
• chemotherapy
• radiation therapy