Total Synthesis of Pagoamide A

Abstract

The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous structural confirmation of pagoamide A.

Keywords

• pagoamide A
• total synthesis
• cyclic depsipeptides