Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition

Céline Portal; Yvonne Lin; Varuni Rastogi; Cornelia Peterson; Samuel Chi-Hung Yiu; James W. Foster; Amber Wilkerson; Igor A. Butovich; Carlo Iomini

doi:10.1038/s42003-023-04632-5

Communications Biology (Mar 2023)

Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition

Céline Portal,
Yvonne Lin,
Varuni Rastogi,
Cornelia Peterson,
Samuel Chi-Hung Yiu,
James W. Foster,
Amber Wilkerson,
Igor A. Butovich,
Carlo Iomini

Affiliations

Céline Portal: Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine
Yvonne Lin: Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine
Varuni Rastogi: Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine
Cornelia Peterson: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine
Samuel Chi-Hung Yiu: Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine
James W. Foster: Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine
Amber Wilkerson: Department of Ophthalmology, University of Texas Southwestern Medical Center
Igor A. Butovich: Department of Ophthalmology, University of Texas Southwestern Medical Center
Carlo Iomini: Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s42003-023-04632-5
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 14

Abstract

Read online

Meibomian gland (MG) cells are ciliated in early stages of development and primary cilium is required to regulate early MG cell patterning within developing glands, with cilia-mediated signaling pathways identified as therapeutic targets.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal