Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Takanori Akagi; Yuta Matsumura; Masaya Yasui; Emiko Minami; Hidemasa Inoue; Takahiro Masuda; Hidetoshi Tozaki-Saitoh; Tomohiko Tamura; Kazue Mizumura; Makoto Tsuda; Hiroshi Kiyama; Kazuhide Inoue

Journal of Pharmacological Sciences (Jan 2014)

Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Takanori Akagi,
Yuta Matsumura,
Masaya Yasui,
Emiko Minami,
Hidemasa Inoue,
Takahiro Masuda,
Hidetoshi Tozaki-Saitoh,
Tomohiko Tamura,
Kazue Mizumura,
Makoto Tsuda,
Hiroshi Kiyama,
Kazuhide Inoue

Affiliations

Takanori Akagi: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan
Yuta Matsumura: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan
Masaya Yasui: Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showaku, Nagoya 446-8550, Japan; Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, Japan
Emiko Minami: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan
Hidemasa Inoue: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan
Takahiro Masuda: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan; Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, Japan
Hidetoshi Tozaki-Saitoh: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan
Tomohiko Tamura: Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
Kazue Mizumura: Department of Physical Therapy, College of Life and Health Sciences, Chubu University, Kasugai, Japan
Makoto Tsuda: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan
Hiroshi Kiyama: Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showaku, Nagoya 446-8550, Japan; Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, Japan
Kazuhide Inoue: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan; Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, Japan; Corresponding author. [email protected]

Journal volume & issue: Vol. 126, no. 2
pp. 172 – 176

Abstract

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Abstract.: We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure. Keywords:: interferon regulatory factor-8, microglia, repeated cold stress

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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