Kidney Research and Clinical Practice (Jun 2012)

A DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL ON THE EFFECT OF FLAXSEED AND OLIVE OILS ON CONSTIPATION OF HEMODIALYSIS PATIENTS: PRELIMINARY RESULTS.

  • Christiane I. Ramos,
  • Aline F.A. de Lima,
  • Daniela G. Grilli,
  • Giovana Sertori,
  • Maria A. Kamimura,
  • Lilian Cuppari

DOI
https://doi.org/10.1016/j.krcp.2012.04.610
Journal volume & issue
Vol. 31, no. 2
p. A88

Abstract

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Mineral oil has been used in the treatment of constipation in hemodialysis patients. Edible oils could also be a good option for treating this symptom. Therefore we aimed to investigate the effect of flaxseed and olive oils on constipation of hemodialysis patients. This trial was conducted for 4 weeks. Constipation was diagnosed by Rome III criterion. Thirty six constipated patients (18M, 51.0±12.2 years) were randomized into Mineral oil (MG; n=11), Flaxseed oil (FG; n=11) and Olive oil (OG; n=14) groups. The initial dose of each oil was 4 ml/d and was adjusted as needed. There was no difference in total oil used among groups (150.7±43.7 ml, 165.8±53.3 ml, 144.4±49.5 ml, respectively; p=0.61). The prevalence of each Roma III criterion item was similar among the groups. MG (%) OG (%) FG (%) 0 wk4 0 wk4 0 wk4 Abdominal pain 54.5 27.3 36.4 9.1* 9.1 0 Straining on defecation 30.8 7.7 34.6 11.5* 34.6 15.4 Lumpy or hard stools 32.3 9.7 39.7 12.9 29.0 12.9 Incomplete evacuation 28.1 18.8 43.8 28.1 28.1 18.8 Anorectal obstruction 29.2 12.5 45.8 4.2* 25.0 12.5 Manual maneuvers 25.0 0 50.0 0* 25.0 0 < 3 evacuation/week 36.8 5.3* 31.6 10.5* 31.6 15.8 This preliminary result suggests that olive oil could be a healthy alternative on treatment of constipation in hemodialysis patients. ⁎ p<0.05; 0 vs wk4.