Immunologic peculiarities of acute viral hepatitis B in dependence on infectious process outcomes

Abstract

The aim of this work was the investigation of immunologic peculiarities of acute viral hepatitis B (AHBV) in dependence on infection process outcomes. To assess immune status, we examined 55 patients with AHBV ( men and women) aged from 18 up to 50 years. Patients were observed from the moment of the admission to the hospital (1-st week jaundice) and up to the period of late reconvalescence (6—8 months after the discharge). The number of blood serum CD3+-, CD4+-, CD8+-, CD16+and CD22+-carrying lymphocytes and blood serum cytokines : IFNa, IFNg, IL-1β, IL-4, TNF-α were investigated. The results of the investigations showed, that immunologic findings in AHBV patients had different changes and depend on the disease outcomes (elimination or preservation of hepatitis B virus).

Keywords

• острый вирусный гепатит в
• лимфоциты
• цитокины
• acute viral hepatitis b
• lymphocytes
• cytokines