Nature Communications (May 2016)

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

  • Pranjul Shah,
  • Joëlle V. Fritz,
  • Enrico Glaab,
  • Mahesh S. Desai,
  • Kacy Greenhalgh,
  • Audrey Frachet,
  • Magdalena Niegowska,
  • Matthew Estes,
  • Christian Jäger,
  • Carole Seguin-Devaux,
  • Frederic Zenhausern,
  • Paul Wilmes

DOI
https://doi.org/10.1038/ncomms11535
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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Research on the interactions between the gut microbiota and human cells would greatly benefit from improved in vitro models. Here, Shah et al. present a modular microfluidics-based model that allows co-culture of human and microbial cells followed by 'omic' molecular analyses of the two cell contingents.