Diabetes, Metabolic Syndrome and Obesity (Sep 2024)

An Investigation of the Correlation Between Retinal Nerve Fiber Layer Thickness with Blood Biochemical Indices and Cognitive Dysfunction in Patients with Type 2 Diabetes Mellitus

  • Zhu X,
  • Jiang D,
  • Zhang H,
  • Cai R,
  • Wang Y,
  • Hua F

Journal volume & issue
Vol. Volume 17
pp. 3315 – 3323

Abstract

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Xiaohui Zhu,1,2 Dongmei Jiang,1 Hongjie Zhang,3 Ruyuan Cai,3 Yuying Wang,1 Fei Hua2 1Department of Endocrinology, Affiliated Hospital 6 of Nantong University, Yancheng, 224000, People’s Republic of China; 2Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, People’s Republic of China; 3Department of Ophthalmology, Affiliated Hospital 6 of Nantong University, Yancheng, 224000, People’s Republic of ChinaCorrespondence: Fei Hua, Email [email protected]: The study aimed to explore the correlation between retinal nerve fiber layer thickness (RNFLT) with blood biochemical indicators and cognitive dysfunction in patients with type 2 diabetes mellitus (T2DM) and the possible mechanism, thereby providing more theoretical basis for the occurrence and prevention of diabetes related complications.Methods: Eighty T2DM patients treated in our hospital from March 2022 to September 2022 were selected as the study subjects, and the clinical data of the patients were retrospectively analyzed. All patients underwent fundus fluorescein angiography (FFA) to analyze the changes in retinal blood vessels. Patients who met the inclusion criteria were divided as the diabetic retinopathy (DR) group (n=46) and simple diabetes group (n=34). The RNFLT, blood biochemical indexes and changes in cognitive functions of the patients were detected. The correlation between RNFLT with blood biochemical indexes and cognitive dysfunction was analyzed.Results: Compared with the simple diabetes group, patients in the DR group had much lower mean, nasal, inferior and superior thicknesses (P 0.05). Compared with the simple diabetes group, patients in the DR group had much higher fasting blood glucose (FBG), hemoglobin A1c (HbA1c), fasting insulin (FINS), insulin resistance (HOMA-IR) index, apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) (P 0.05).Conclusion: DR patients had significantly reduced RNFLT, elevated levels of blood glucose related indicators, and cognitive dysfunction. There existed a correlation between RNFLT and FBG, HbA1c, HOMA-IR index, TMT-A, TMT-B and MMSE.Keywords: type 2 diabetes mellitus, retinal nerve fiber thickness, blood biochemical indicators, cognitive dysfunction, correlation

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