Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids

Xiangan Liu; Pratick Khara; Matthew L. Baker; Peter J. Christie; Bo Hu

doi:10.1038/s41467-022-28058-5

Nature Communications (Jan 2022)

Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids

Xiangan Liu,
Pratick Khara,
Matthew L. Baker,
Peter J. Christie,
Bo Hu

Affiliations

Xiangan Liu: Department of Microbiology and Molecular Genetics, McGovern Medical School
Pratick Khara: Department of Microbiology and Molecular Genetics, McGovern Medical School
Matthew L. Baker: Department of Biochemistry and Molecular Biology, McGovern Medical School
Peter J. Christie: Department of Microbiology and Molecular Genetics, McGovern Medical School
Bo Hu: Department of Microbiology and Molecular Genetics, McGovern Medical School

DOI: https://doi.org/10.1038/s41467-022-28058-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Bacteria conjugatively transfer DNA through type IV secretion systems (T4SSs). Here, the authors report the structure of a T4SS outer-membrane core complex (OMCC), revealing how a distinct C13:C17 symmetry mismatch exhibited by peripheral ring and central cone substructures is accommodated.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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