Optimization of compositional manipulation for hydroxyapatite modified with boron oxide and graphene oxide for medical applications

Mohamed T. Elabbasy; Fahad D. Algahtani; Helal F. Al-Harthi; M.F.H. Abd El-Kader; Essam Hassan Eldrehmy; Ghada I. Abd El-Rahman; M.A. El-Morsy; A.A. Menazea

Journal of Materials Research and Technology (May 2022)

Optimization of compositional manipulation for hydroxyapatite modified with boron oxide and graphene oxide for medical applications

Mohamed T. Elabbasy,
Fahad D. Algahtani,
Helal F. Al-Harthi,
M.F.H. Abd El-Kader,
Essam Hassan Eldrehmy,
Ghada I. Abd El-Rahman,
M.A. El-Morsy,
A.A. Menazea

Affiliations

Mohamed T. Elabbasy: Department of Public Health, College of Public Health and Health Informatics, University of Ha’il, Ha’il, 2440, Saudi Arabia; Food Control Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt
Fahad D. Algahtani: Department of Public Health, College of Public Health and Health Informatics, University of Ha’il, Ha’il, 2440, Saudi Arabia
Helal F. Al-Harthi: Department of Biology, Turabah University College, Taif University, Taif, Saudi Arabia
M.F.H. Abd El-Kader: Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt
Essam Hassan Eldrehmy: Department of Biology, Turabah University College, Taif University, Taif, Saudi Arabia; Department of Microbiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt
Ghada I. Abd El-Rahman: Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt
M.A. El-Morsy: College of Science and Humanities in Al-Kharj, Physics Department, Plasma Technology and Material Science Unit, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia; Physics Department, Faculty of Science, University of Damietta, New Damietta 34517, Egypt; Corresponding author.
A.A. Menazea: Laser Technology Unit, Center of Excellent for Advanced Science, National Research Center, Dokki, 12622, Giza, Egypt; Spectroscopy Department, Physics Research Institute, National Research Centre, Dokki, 12622, Giza, Egypt

Journal volume & issue: Vol. 18
pp. 5419 – 5431

Abstract

Read online

Bone tissue engineering is the most used technology in recent years for repairing damaged bones. A novel heterogeneous biomaterial is prepared and studied to be suggested as a promising bone substitute biomaterial, based on three different nanoparticles: hydroxyapatite (HAP), boron oxide (B2O3), and graphene oxide (GO) a triple nanocomposite is designed HAP/B2O3/GO. This hybrid scaffold is analyzed with XRD to examine the crystalline structure of HAP/B2O3/GO and shows its crystal planes. Moreover, the interaction between the three nanoparticles and their distinctive active functional groups is illustrated with FTIR analysis. Further, TEM micrographs demonstrate the structural alteration and the uniform incorporation of HAP and B2O3 into GO sheets with an average length of 30 nm and diameter of 6 nm for HAP, and a size of 8 mm for B2O3. Furthermore, SEM micrographs reveal the porous structure of HAP/B2O3/GO with a grain size of 5–10 nm. The maximum roughness average value is obtained by HAP/B2O3/GO which is 11.04 nm. Besides, HAP/B2O3/GO nanocomposite shows the highest cell viability value of 96.1 ± 1.2%. The bacterial toxicity of HAP/B2O3/GO is confirmed with the obtained inhibition zone against Escherichia coli and Staphylococcus aureus of 15.7 ± 1.1 mm and 16.2 ± 0.8 mm respectively. In addition, the hardness of the triple composite is improved showing a maximum value of 3.7 ± 0.3 GPa. Distinctly, the addition of B2O3 to HAP and GO nanosheets alter the morphological properties and enhances the roughness parameters of HAP/B2O3/GO. Besides, HAP/B2O3/GO shows improved porosity, cell viability, and biodegradability. Hence, studying HAP/B2O3/GO nanocomposite with different scans and analyses reveals its porous integrated structure and shows an excellent antibacterial property, so that HAP/B2O3/GO composite can be suggested as a promising bone substitute biomaterial.

Published in Journal of Materials Research and Technology

ISSN: 2238-7854 (Print); 2214-0697 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Mining engineering. Metallurgy
Website: https://www.journals.elsevier.com/journal-of-materials-research-and-technology/

About the journal

Abstract

Keywords