Effect of binder type on physical and in vitro properties of high dose inosine acedoben dimepranol tablets

Abstract

The present work was conducted with the aim to formulate and evaluate the immediate release of 1000 mg tablets containing Inosine Acedoben Dimepranol (IAD). All the samples of the tablets containing 1000 mg IAD were prepared by conventional wet granulation method. Various type of binders like povidone, wheat starch, pregelatinized starch (starch 1500TM , Colorcon), microcrystalline cellulose and macrogol 6000 were used to prepare some series of tablets. Granules were evaluated for pre-compression parameters and tablets were evaluated for post- compression parameters. The composition batch № IAD1000 L04 was found to be the best for producing IAD 1000 mg tablets. The optimal lubricant system is glycerol dibehenate at a concentration of 2.94% plus magnesium stearate at a concentration of 0.46%. Optimized formulation was evaluated for in-vitro dissolution test. Stability studies were performed for the selected composition.