Research progress on the material basis and action mechanism of LuQi Formula in treating heart failure

Abstract

Heart failure is the terminal stage of cardiovascular diseases. In the population-aging trend, it remains a serious social problem with high morbidity, mortality, and rehospitalization rates. Traditional Chinese medicine has long been used to treat heart failure. LuQi Formula was modified by Professor Zhou Hua of Shuguang Hospital, Shanghai, based on years of clinical experience and the concept of the “heart-kidney intersection.” It has been proven effective in the treatment of heart failure, and is beneficial in inhibiting myocardial fibrosis, decreasing collagen deposition and brain natriuretic peptide levels, improving heart function in rats with acute myocardial infarction, and affecting adenosine triphosphate production. In this review, we summarized the clinical and laboratory research on LuQi Formula, and the mechanism of the cardioprotective effect of each medicine in this recipe. This review offers a theoretical basis and research direction for further mechanistic studies on LuQi Formula to foster its development into new cardiovascular drugs.

Keywords

• Heart failure
• LuQi Formula
• Clinical application
• Material basis
• Mechanism study