Nature Communications (May 2022)
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift
- Yang Zhang,
- Laura Garcia-Ibanez,
- Carolin Ulbricht,
- Laurence S. C. Lok,
- Jeremy A. Pike,
- Jennifer Mueller-Winkler,
- Thomas W. Dennison,
- John R. Ferdinand,
- Cameron J. M. Burnett,
- Juan C. Yam-Puc,
- Lingling Zhang,
- Raul Maqueda Alfaro,
- Yousuke Takahama,
- Izumi Ohigashi,
- Geoffrey Brown,
- Tomohiro Kurosaki,
- Victor L. J. Tybulewicz,
- Antal Rot,
- Anja E. Hauser,
- Menna R. Clatworthy,
- Kai-Michael Toellner
Affiliations
- Yang Zhang
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Laura Garcia-Ibanez
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Carolin Ulbricht
- Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Laurence S. C. Lok
- University of Cambridge Molecular Immunity Unit, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus
- Jeremy A. Pike
- Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham
- Jennifer Mueller-Winkler
- The Francis Crick Institute
- Thomas W. Dennison
- University of Cambridge Molecular Immunity Unit, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus
- John R. Ferdinand
- University of Cambridge Molecular Immunity Unit, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus
- Cameron J. M. Burnett
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Juan C. Yam-Puc
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Lingling Zhang
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Raul Maqueda Alfaro
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Yousuke Takahama
- Thymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health
- Izumi Ohigashi
- Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima
- Geoffrey Brown
- Department of Cell Biology, Center for Research and Advanced Studies, The National Polytechnic Institute, Cinvestav-IPN, Av. IPN 2508, San Pedro Zacatenco, Gustavo A. Madero
- Tomohiro Kurosaki
- Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University
- Victor L. J. Tybulewicz
- The Francis Crick Institute
- Antal Rot
- Centre for Microvascular Research, The William Harvey Research Institute, Queen Mary University London
- Anja E. Hauser
- Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Menna R. Clatworthy
- University of Cambridge Molecular Immunity Unit, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus
- Kai-Michael Toellner
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- DOI
- https://doi.org/10.1038/s41467-022-29978-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Activated B cell enter germinal centers (GC) to become plasma cells and memory B cells. Here the authors show that some memory B cells recycle to GC via CCL-21 mediated chemotaxis to deliver antigens from the lymph node subcapsular sinus (SCS) to potentially contribute to affinity maturation and antigenic drift.
