STUDIES OF EXPERIMENTAL MYOCARDITIS IN CONDITIONS OF SYNERGISTIC ACTION OF SEROTONINERGIC AND CHOLINERGIC FIBERS

Abstract

Synergistic action of serotoninergic and cholinergic fibers resulted in augmented vagus heart deceleration when stellate ganglion stimulation was added to vagus nerve stimulation. In such cases expreimental animals developed myocarditis with increased tissue contents of acethylcholine and catecholamines. Blocking S3-serotonin receptors of vegetative ganglia and S1,2 – receptors of the myocardium decreased severity of myocarditis.

Keywords

• heart
• stellate ganglion
• vagus nerve
• serotonin