Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Nov 2015)
Evaluation of Serum Omentin Concentration and Its Association with Cardiovascular Risk Factors in Patients Undergoing Hemodialysis
Abstract
BACKGROUND AND OBJECTIVE: Inconsistent findings have been reported regarding the concentration of serum omentin in patients undergoing hemodialysis and healthy individuals. Omentin is correlated with several cardiovascular risk factors such as obesity, metabolic syndrome, atherosclerosis and inflammation. This study aimed to compare serum omentin concentration between hemodialysis patients and healthy subjects and determine its correlation with cardiovascular risk factors. METHODS: This case-control study was conducted on 85 subjects divided into two groups of hemodialysis (n=55) and control (n=30). Serum omentin concentration and C-reactive protein (CRP) level were measured using ELISA and immunoturbidimetric method, respectively. Required data including age, cardiovascular risk factors, duration of dialysis, body mass index and history of cardiovascular diseases were collected via interviews and blood sampling and compared between groups. FINDINGS: In this study, mean age of subjects in hemodialysis and control groups was 50.81±13.39 and 49.70±9.32 years, respectively (age range: 19-80 years). Serum omentin concentration was significantly higher in patients undergoing hemodialysis compared to control subjects (2.15±1.46 vs. 0.78±0.07 &mug/ml, respectively) (p=0.0001). In addition, systolic blood pressure, blood glucose, creatinine and CRP were significantly higher in hemodialysis patients compared to control subjects, while levels of cholesterol, low-density lipoprotein, high-density lipoprotein and hemoglobin were significantly lower. Also, a significant positive correlation was observed between serum omentin and creatinine in all studied subjects (p=0.001, r=0.397). However, this correlation was not significant in patients undergoing hemodialysis. A positive correlation was found between serum omentin and blood glucose in the study population (p=0.001, r=0.590), and this correlation was less significant in hemodialysis patients (p=0.045 r=-244). Moreover, a significant negative correlation was observed between serum levels of omentin and triglyceride in hemodialysis patients (p=0.012, r=-244). No correlations were found between serum omentin and factors such as CRP, albumin, obesity and history of cardiovascular diseases or diabetes. CONCLUSION: According to the results of this study, omentin concentration has a significant increase in patients undergoing hemodialysis compared to healthy subjects. In addition, serum omentin in these patients is positively correlated with a number of cardiovascular risk factors.
