Emerging Infectious Diseases (Apr 2022)

Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers

  • Eric D. Laing,
  • Carol D. Weiss,
  • Emily C. Samuels,
  • Si’Ana A. Coggins,
  • Wei Wang,
  • Richard Wang,
  • Russell Vassell,
  • Spencer L. Sterling,
  • Marana S. Tso,
  • Tonia Conner,
  • Emilie Goguet,
  • Matthew Moser,
  • Belinda M. Jackson-Thompson,
  • Luca Illinik,
  • Julian Davies,
  • Orlando Ortega,
  • Edward Parmelee,
  • Monique Hollis-Perry,
  • Santina E. Maiolatesi,
  • Gregory Wang,
  • Kathleen F. Ramsey,
  • Anatalio E. Reyes,
  • Yolanda Alcorta,
  • Mimi A. Wong,
  • Alyssa R. Lindrose,
  • Christopher A. Duplessis,
  • David R. Tribble,
  • Allison M.W. Malloy,
  • Timothy H. Burgess,
  • Simon D. Pollett,
  • Cara H. Olsen,
  • Christopher C. Broder,
  • Edward Mitre

DOI
https://doi.org/10.3201/eid2804.212037
Journal volume & issue
Vol. 28, no. 4
pp. 828 – 832

Abstract

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.

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