Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases

John R. van Sörnsen de Koste; Claire C. van Vliet; Famke L. Schneiders; Anna M.E. Bruynzeel; Berend J. Slotman; Miguel A. Palacios; Suresh Senan

Physics and Imaging in Radiation Oncology (Oct 2021)

Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases

John R. van Sörnsen de Koste,
Claire C. van Vliet,
Famke L. Schneiders,
Anna M.E. Bruynzeel,
Berend J. Slotman,
Miguel A. Palacios,
Suresh Senan

Affiliations

John R. van Sörnsen de Koste: Corresponding author.; Department of Radiation Oncology, Amsterdam University Medical Centers, location VUmc, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Claire C. van Vliet: Department of Radiation Oncology, Amsterdam University Medical Centers, location VUmc, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Famke L. Schneiders: Department of Radiation Oncology, Amsterdam University Medical Centers, location VUmc, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Anna M.E. Bruynzeel: Department of Radiation Oncology, Amsterdam University Medical Centers, location VUmc, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Berend J. Slotman: Department of Radiation Oncology, Amsterdam University Medical Centers, location VUmc, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Miguel A. Palacios: Department of Radiation Oncology, Amsterdam University Medical Centers, location VUmc, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Suresh Senan: Department of Radiation Oncology, Amsterdam University Medical Centers, location VUmc, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands

Journal volume & issue: Vol. 20
pp. 1 – 4

Abstract

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Stereotactic ablative radiotherapy (SABR) planning for adrenal metastases aims to minimize doses to the adjacent kidney. Renal dose constraints for SABR delivery are not well defined. In 20 patients who underwent MR-guided breath-hold SABR in five daily fractions of 8–10 Gy, ipsilateral renal volumes receiving ≥20 Gy best correlated with loss of renal volumes, with median renal volume reduction being 6% (range: 3%-11%, 10th-90th percentiles). Organ function did not deteriorate in 18 patients, who had post treatment renal function tests available. This suggests that the ipsilateral renal volume receiving 20 Gy can be used as partial organ dose constraint for SABR to targets in the upper abdomen.

Published in Physics and Imaging in Radiation Oncology

ISSN: 2405-6316 (Online)
Publisher: Elsevier
Country of publisher: Ireland
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/physics-and-imaging-in-radiation-oncology/

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