miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy

Shawn S. Badal; Yin Wang; Jianyin Long; David L. Corcoran; Benny H. Chang; Luan D. Truong; Yashpal S. Kanwar; Paul A. Overbeek; Farhad R. Danesh

doi:10.1038/ncomms12076

Nature Communications (Jun 2016)

miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy

Shawn S. Badal,
Yin Wang,
Jianyin Long,
David L. Corcoran,
Benny H. Chang,
Luan D. Truong,
Yashpal S. Kanwar,
Paul A. Overbeek,
Farhad R. Danesh

Affiliations

Shawn S. Badal: Section of Nephrology, The University of Texas MD Anderson Cancer Center
Yin Wang: Section of Nephrology, The University of Texas MD Anderson Cancer Center
Jianyin Long: Section of Nephrology, The University of Texas MD Anderson Cancer Center
David L. Corcoran: Center for Genomic and Computational Biology, Duke University
Benny H. Chang: Department of Molecular and Cellular Biology, Baylor College of Medicine
Luan D. Truong: Department of Pathology and Molecular Medicine, Houston Methodist Hospital
Yashpal S. Kanwar: Department of Pathology, Feinberg School of Medicine, Northwestern University
Paul A. Overbeek: Department of Molecular and Cellular Biology, Baylor College of Medicine
Farhad R. Danesh: Section of Nephrology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/ncomms12076
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Podocyte injury is central to kidney dysfunction in diabetic nephropathy. Here the authors show that Msk2 is a target of miR-93 and this interaction mediates pathogenic chromatin remodelling in diabetic nephropathy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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