Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells

Shouguo Gao; Zhijie Wu; Bradley Arnold; Carrie Diamond; Sai Batchu; Valentina Giudice; Lemlem Alemu; Diego Quinones Raffo; Xingmin Feng; Sachiko Kajigaya; John Barrett; Sawa Ito; Neal S. Young

doi:10.1038/s41467-022-29175-x

Nature Communications (Apr 2022)

Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells

Shouguo Gao,
Zhijie Wu,
Bradley Arnold,
Carrie Diamond,
Sai Batchu,
Valentina Giudice,
Lemlem Alemu,
Diego Quinones Raffo,
Xingmin Feng,
Sachiko Kajigaya,
John Barrett,
Sawa Ito,
Neal S. Young

Affiliations

Shouguo Gao: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Zhijie Wu: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Bradley Arnold: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Carrie Diamond: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Sai Batchu: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Valentina Giudice: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Lemlem Alemu: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Diego Quinones Raffo: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Xingmin Feng: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Sachiko Kajigaya: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
John Barrett: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
Sawa Ito: Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh
Neal S. Young: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-022-29175-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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T cell large granular lymphocyte leukemia (T-LGLL) and the cellular phenotype underlying response to therapy is not well understood. Here the authors use single cell sequencing to better understand changes in T cell clonal frequency and gene expression before and after therapy in T-LGLL.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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