Nature Communications (Nov 2017)
Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
- M. H. Al-Mossawi,
- L. Chen,
- H. Fang,
- A. Ridley,
- J. de Wit,
- N. Yager,
- A. Hammitzsch,
- I. Pulyakhina,
- B. P. Fairfax,
- D. Simone,
- Yao Yi,
- S. Bandyopadhyay,
- K. Doig,
- R Gundle,
- B. Kendrick,
- F. Powrie,
- J. C. Knight,
- P. Bowness
Affiliations
- M. H. Al-Mossawi
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- L. Chen
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- H. Fang
- Wellcome Trust Centre for Human Genetics, Nuffield department of medicine, University of Oxford
- A. Ridley
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- J. de Wit
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- N. Yager
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- A. Hammitzsch
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- I. Pulyakhina
- Wellcome Trust Centre for Human Genetics, Nuffield department of medicine, University of Oxford
- B. P. Fairfax
- Wellcome Trust Centre for Human Genetics, Nuffield department of medicine, University of Oxford
- D. Simone
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- Yao Yi
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- S. Bandyopadhyay
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- K. Doig
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- R Gundle
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- B. Kendrick
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- F. Powrie
- Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- J. C. Knight
- Wellcome Trust Centre for Human Genetics, Nuffield department of medicine, University of Oxford
- P. Bowness
- Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-017-01771-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Spondyloarthritis is an inflammatory disease with Th17 cells implicated in the pathogenesis. Here the authors show that patients with spondyloarthritis have increased numbers of GM-CSF-secreting blood and synovial lymphocytes, Th17 or not, that carry a unique transcriptional profile including enhanced GPR65 expression.
