HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130

Anja Göder; Claudia Emmerich; Teodora Nikolova; Nicole Kiweler; Maria Schreiber; Toni Kühl; Diana Imhof; Markus Christmann; Thorsten Heinzel; Günter Schneider; Oliver H. Krämer

doi:10.1038/s41467-018-03096-0

Nature Communications (Feb 2018)

HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130

Anja Göder,
Claudia Emmerich,
Teodora Nikolova,
Nicole Kiweler,
Maria Schreiber,
Toni Kühl,
Diana Imhof,
Markus Christmann,
Thorsten Heinzel,
Günter Schneider,
Oliver H. Krämer

Affiliations

Anja Göder: Institute of Toxicology, University Medical Center Mainz
Claudia Emmerich: University of Jena, Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine (CMB)
Teodora Nikolova: Institute of Toxicology, University Medical Center Mainz
Nicole Kiweler: Institute of Toxicology, University Medical Center Mainz
Maria Schreiber: University of Jena, Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine (CMB)
Toni Kühl: Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn
Diana Imhof: Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn
Markus Christmann: Institute of Toxicology, University Medical Center Mainz
Thorsten Heinzel: University of Jena, Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine (CMB)
Günter Schneider: Klinik und Poliklinik für Innere Medizin II, Technical University of Munich
Oliver H. Krämer: Institute of Toxicology, University Medical Center Mainz

DOI: https://doi.org/10.1038/s41467-018-03096-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Checkpoint kinases control cell cycle progression via the regulation of many key regulators. Here the authors demonstrate how HDAC1 and HDAC2 modulate checkpoint kinase signalling via the suppression of PR130, a regulatory subunit of the trimeric serine/threonine phosphatase 2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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