Nature Communications (Jun 2022)
ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription
- Chunhong Yu,
- Xiaoyun Lei,
- Fang Chen,
- Song Mao,
- Lu Lv,
- Honglu Liu,
- Xueying Hu,
- Runhan Wang,
- Licong Shen,
- Na Zhang,
- Yang Meng,
- Yunfan Shen,
- Jiale Chen,
- Pishun Li,
- Shi Huang,
- Changwei Lin,
- Zhuohua Zhang,
- Kai Yuan
Affiliations
- Chunhong Yu
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Xiaoyun Lei
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Fang Chen
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Song Mao
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Lu Lv
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Honglu Liu
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Xueying Hu
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Runhan Wang
- Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Licong Shen
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Na Zhang
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Yang Meng
- Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Yunfan Shen
- Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Jiale Chen
- Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Pishun Li
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Shi Huang
- Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Changwei Lin
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Zhuohua Zhang
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- Kai Yuan
- Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University
- DOI
- https://doi.org/10.1038/s41467-022-31197-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Here the authors show mutation of the BAF chromatin remodeler subunit ARID1A results in an ARID1B-dependent upregulation of HERVH, an ERV required for the pluripotency regulatory network. These HERVH RNAs can partition into BRD4 foci, affecting BRD4-dependent transcription. Suppression of HERVH in colorectal cancer cells and patient-derived organoids impairs tumor growth.
