Nature Communications (Aug 2021)
GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
- K. Saidas Nair,
- Chitrangda Srivastava,
- Robert V. Brown,
- Swanand Koli,
- Hélène Choquet,
- Hong Soon Kang,
- Yien-Ming Kuo,
- Sara A. Grimm,
- Caleb Sutherland,
- Alexandra Badea,
- G. Allan Johnson,
- Yin Zhao,
- Jie Yin,
- Kyoko Okamoto,
- Graham Clark,
- Terete Borrás,
- Gulab Zode,
- Krishnakumar Kizhatil,
- Subhabrata Chakrabarti,
- Simon W. M. John,
- Eric Jorgenson,
- Anton M. Jetten
Affiliations
- K. Saidas Nair
- Department of Ophthalmology and Department of Anatomy, School of Medicine, University of California, San Francisco
- Chitrangda Srivastava
- Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health
- Robert V. Brown
- Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health
- Swanand Koli
- Department of Ophthalmology, School of Medicine, University of California, San Francisco
- Hélène Choquet
- Kaiser Permanente Northern California, Division of Research
- Hong Soon Kang
- Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health
- Yien-Ming Kuo
- Department of Ophthalmology, School of Medicine, University of California, San Francisco
- Sara A. Grimm
- Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, National Institutes of Health
- Caleb Sutherland
- Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health
- Alexandra Badea
- Center for In Vivo Microscopy, Department of Radiology, Duke University
- G. Allan Johnson
- Center for In Vivo Microscopy, Department of Radiology, Duke University
- Yin Zhao
- Department of Ophthalmology, School of Medicine, University of California, San Francisco
- Jie Yin
- Kaiser Permanente Northern California, Division of Research
- Kyoko Okamoto
- Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health
- Graham Clark
- The Jackson Laboratory
- Terete Borrás
- Department of Ophthalmology, University of North Carolina School of Medicine
- Gulab Zode
- Department of Pharmacology and Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center
- Krishnakumar Kizhatil
- The Jackson Laboratory
- Subhabrata Chakrabarti
- Brien Holden Eye Research Centre, L. V. Prasad Eye Institute
- Simon W. M. John
- The Jackson Laboratory
- Eric Jorgenson
- Regeneron Pharmaceuticals, Inc
- Anton M. Jetten
- Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-021-25181-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. Here, the authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular pressure, and as a glaucoma risk gene.
