Spontaneous Coronary Artery Dissection in Females With the Fragile X FMR1 Premutation

Forrest J. McKenzie, BS; Nattaporn Tassanakijpanich, MD; Kelly C. Epps, MD; S. Kimara March, MD; Randi J. Hagerman, MD

JACC: Case Reports (Jan 2020)

Spontaneous Coronary Artery Dissection in Females With the Fragile X FMR1 Premutation

Forrest J. McKenzie, BS,
Nattaporn Tassanakijpanich, MD,
Kelly C. Epps, MD,
S. Kimara March, MD,
Randi J. Hagerman, MD

Affiliations

Forrest J. McKenzie, BS: Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, California; Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California
Nattaporn Tassanakijpanich, MD: Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
Kelly C. Epps, MD: Inova Heart and Vascular Institute, Department of Cardiology, Falls Church, Virginia
S. Kimara March, MD: University of Minnesota Physicians, Department of Cardiology, Minneapolis, Minnesota
Randi J. Hagerman, MD: Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, California; Department of Pediatrics, University of California Davis School of Medicine, Sacramento, California; Address for correspondence: Dr. Randi J. Hagerman, MIND Institute, University of California Davis Medical Center, 2825 50th Street, Sacramento, California 95817.

Journal volume & issue: Vol. 2, no. 1
pp. 40 – 44

Abstract

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This paper reports 2 cases of female carriers of the FMR1 premutation for developing spontaneous coronary artery dissection (SCAD). These women had classical presentations of premutation symptoms, including anxiety, depression, and connective tissue problems, all of which can contribute to SCAD. These cases suggest a possible connection between the fragile X premutation and a predisposition to SCAD. (Level of Difficulty: Intermediate.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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