Journal of Extracellular Vesicles (Aug 2015)
Extracellular RNAs: development as biomarkers of human disease
- Joseph F. Quinn,
- Tushar Patel,
- David Wong,
- Saumya Das,
- Jane E. Freedman,
- Louise C. Laurent,
- Bob S. Carter,
- Fred Hochberg,
- Kendall Van Keuren-Jensen,
- Matt Huentelman,
- Robert Spetzler,
- M. Yashar S. Kalani,
- Jorge Arango,
- P. David Adelson,
- Howard L. Weiner,
- Roopali Gandhi,
- Beatrice Goilav,
- Chaim Putterman,
- Julie A. Saugstad
Affiliations
- Joseph F. Quinn
- Department of Neurology, Oregon Health & Science University, Portland, OR, USA
- Tushar Patel
- Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, FL, USA
- David Wong
- School of Dentistry, Department of Head and Neck Surgery, University of California at Los Angeles, Los Angeles, CA, USA
- Saumya Das
- Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
- Jane E. Freedman
- Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
- Louise C. Laurent
- Department of Reproductive Medicine, University of California at San Diego, San Diego, CA, USA
- Bob S. Carter
- Department of Neurosurgery, University of California at San Diego, San Diego, CA, USA
- Fred Hochberg
- Department of Neurosurgery, University of California at San Diego, San Diego, CA, USA
- Kendall Van Keuren-Jensen
- Translational Genomics Research Institute, Phoenix, AZ, USA
- Matt Huentelman
- Translational Genomics Research Institute, Phoenix, AZ, USA
- Robert Spetzler
- Barrow Neurological Institute, Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA
- M. Yashar S. Kalani
- Barrow Neurological Institute, Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA
- Jorge Arango
- Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA
- P. David Adelson
- Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA
- Howard L. Weiner
- Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
- Roopali Gandhi
- Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
- Beatrice Goilav
- Division of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA
- Chaim Putterman
- Division of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
- Julie A. Saugstad
- Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA
- DOI
- https://doi.org/10.3402/jev.v4.27495
- Journal volume & issue
-
Vol. 4,
no. 0
pp. 1 – 15
Abstract
Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage, multiple sclerosis and placental disorders. Progress to date and the plans for future studies are outlined.
Keywords