A tRNA half modulates translation as stress response in Trypanosoma brucei

Roger Fricker; Rebecca Brogli; Hannes Luidalepp; Leander Wyss; Michel Fasnacht; Oliver Joss; Marek Zywicki; Mark Helm; André Schneider; Marina Cristodero; Norbert Polacek

doi:10.1038/s41467-018-07949-6

Nature Communications (Jan 2019)

A tRNA half modulates translation as stress response in Trypanosoma brucei

Roger Fricker,
Rebecca Brogli,
Hannes Luidalepp,
Leander Wyss,
Michel Fasnacht,
Oliver Joss,
Marek Zywicki,
Mark Helm,
André Schneider,
Marina Cristodero,
Norbert Polacek

Affiliations

Roger Fricker: Department of Chemistry and Biochemistry, University of Bern
Rebecca Brogli: Department of Chemistry and Biochemistry, University of Bern
Hannes Luidalepp: Department of Chemistry and Biochemistry, University of Bern
Leander Wyss: Department of Chemistry and Biochemistry, University of Bern
Michel Fasnacht: Department of Chemistry and Biochemistry, University of Bern
Oliver Joss: Department of Chemistry and Biochemistry, University of Bern
Marek Zywicki: Department of Computational Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University
Mark Helm: Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University of Mainz
André Schneider: Department of Chemistry and Biochemistry, University of Bern
Marina Cristodero: Department of Chemistry and Biochemistry, University of Bern
Norbert Polacek: Department of Chemistry and Biochemistry, University of Bern

DOI: https://doi.org/10.1038/s41467-018-07949-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

Trypanosoma brucei mainly relies on translational regulation to adjust gene expression, but details are unclear. Here the authors show that, under stress conditions, tRNAThr half level increases, associates with ribosomes and polysomes, and stimulates protein synthesis by facilitating mRNA loading.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal