Nature Communications (Sep 2020)
A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A
- Jacopo Enotarpi,
- Marta Tontini,
- Cristiana Balocchi,
- Daan van der Es,
- Ludovic Auberger,
- Evita Balducci,
- Filippo Carboni,
- Daniela Proietti,
- Daniele Casini,
- Dmitri V. Filippov,
- Hermen S. Overkleeft,
- Gijsbert A. van der Marel,
- Cinzia Colombo,
- Maria Rosaria Romano,
- Francesco Berti,
- Paolo Costantino,
- Jeroen D. C. Codeé,
- Luigi Lay,
- Roberto Adamo
Affiliations
- Jacopo Enotarpi
- Department of Chemistry and CRC Polymeric Materials (LaMPo), University of Milan
- Marta Tontini
- GSK
- Cristiana Balocchi
- GSK
- Daan van der Es
- Department of Bioorganic Synthesis, Leiden University
- Ludovic Auberger
- Department of Chemistry and CRC Polymeric Materials (LaMPo), University of Milan
- Evita Balducci
- GSK
- Filippo Carboni
- GSK
- Daniela Proietti
- GSK
- Daniele Casini
- GSK
- Dmitri V. Filippov
- Department of Bioorganic Synthesis, Leiden University
- Hermen S. Overkleeft
- Department of Bioorganic Synthesis, Leiden University
- Gijsbert A. van der Marel
- Department of Bioorganic Synthesis, Leiden University
- Cinzia Colombo
- Department of Chemistry and CRC Polymeric Materials (LaMPo), University of Milan
- Maria Rosaria Romano
- GSK
- Francesco Berti
- GSK
- Paolo Costantino
- GSK
- Jeroen D. C. Codeé
- Department of Bioorganic Synthesis, Leiden University
- Luigi Lay
- Department of Chemistry and CRC Polymeric Materials (LaMPo), University of Milan
- Roberto Adamo
- GSK
- DOI
- https://doi.org/10.1038/s41467-020-18279-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
The Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) is a component of commercial vaccines, but is unstable. Here, the authors generate glycomimetic oligomers that demonstrate higher stability than their natural counterparts and induce protective antibodies in mice.
