Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

Chad N. Brocker; Donghwan Kim; Tisha Melia; Kritika Karri; Thomas J. Velenosi; Shogo Takahashi; Daisuke Aibara; Jessica A. Bonzo; Moshe Levi; David J. Waxman; Frank J. Gonzalez

doi:10.1038/s41467-020-19554-7

Nature Communications (Nov 2020)

Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

Chad N. Brocker,
Donghwan Kim,
Tisha Melia,
Kritika Karri,
Thomas J. Velenosi,
Shogo Takahashi,
Daisuke Aibara,
Jessica A. Bonzo,
Moshe Levi,
David J. Waxman,
Frank J. Gonzalez

Affiliations

Chad N. Brocker: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Donghwan Kim: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Tisha Melia: Department of Biology and Bioinformatics Program, Boston University
Kritika Karri: Department of Biology and Bioinformatics Program, Boston University
Thomas J. Velenosi: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Shogo Takahashi: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Daisuke Aibara: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Jessica A. Bonzo: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Moshe Levi: Biochemistry and Molecular & Cellular Biology, Georgetown University
David J. Waxman: Department of Biology and Bioinformatics Program, Boston University
Frank J. Gonzalez: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-020-19554-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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PPAR-alpha is a ligand responsive transcription factor that mediates energy metabolism during fasting in the liver. Here the authors show that Gm15441 is a PPAR-alpha dependent lncRNA that prevents the expression of its antisense transcript, thioredoxin interacting protein (TXNIP), and attenuates inflammasome activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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