Ameliorative effect of licorice extract against the detrimental effect of glyphosate-based pesticide: Toxicity and health

Ahmed N. Elkattan; Sayad El-saadany; Mohamed Azzazy; Tarek M. Okda; Maha Mamdouh; Osama Ahmed; Ali H. El-Far; Manar ElKhayat; Ghadeer M. Albadrani; Muath Q. Al-Ghadi; Mohamed M. Abdel-Daim; Hala El Daous

Heliyon (May 2024)

Ameliorative effect of licorice extract against the detrimental effect of glyphosate-based pesticide: Toxicity and health

Ahmed N. Elkattan,
Sayad El-saadany,
Mohamed Azzazy,
Tarek M. Okda,
Maha Mamdouh,
Osama Ahmed,
Ali H. El-Far,
Manar ElKhayat,
Ghadeer M. Albadrani,
Muath Q. Al-Ghadi,
Mohamed M. Abdel-Daim,
Hala El Daous

Affiliations

Ahmed N. Elkattan: Institute of Graduate Studies and Environmental Research, DamanhourUniversity, 22511, Damanhour, Egypt
Sayad El-saadany: Biochemistry Department, Faculty of Agriculture, Zagazig University, 44511, Zagazig, Egypt
Mohamed Azzazy: Plant Ecology, Institute of Desert Studies, Sadat City University, 32897, El Sadat City, Egypt
Tarek M. Okda: Biochemistry Department, Faculty of Pharmacy, Damanhur University, 22511, Damanhour, Egypt
Maha Mamdouh: Department of Physiology, Faculty of Veterinary Medicine, Benha University, 13736, Mushtuhur, Toukh, Qalioubia, Egypt
Osama Ahmed: Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Benha University, 13736, Mushtuhur, Toukh, Qalioubia, Egypt
Ali H. El-Far: Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, 22511, Damanhour, Egypt
Manar ElKhayat: Department of Bacteriology, Immunology and Mycology, Faculty of Veterinary Medicine, Benha University, 13736, Mushtuhur, Toukh, Qalioubia, Egypt
Ghadeer M. Albadrani: Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, 84428, Riyadh, 11671, Saudi Arabia
Muath Q. Al-Ghadi: Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia
Mohamed M. Abdel-Daim: Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah, 21442, Saudi Arabia; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt
Hala El Daous: Faculty of Veterinary Medicine, Benha University, 13736, Mushtuhur, Toukh, Qalioubia, Egypt; Corresponding author. Department of Hygiene and Veterinary Management, Faculty of Veterinary Medicine, Benha University, Egypt.

Journal volume & issue: Vol. 10, no. 10
p. e31623

Abstract

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This study sheds the light on the potential of licorice (Glycyrrhiza glabra) root aqueous extract as a cornerstone for mitigating and detoxifying the residues of the widely used agricultural Glyphosate-based pesticides (GBPs). This study examined the GBPs toxic effects on kidney, liver, thyroid functions, and apoptosis using 50 adult male albino rats. All rats were divided into 5 groups, with 10 each. Control: served as untreated rats. GBP: rats were treated with 1 mL glyphosate solution 24 % orally for three weeks. The glyphosate-treated rats were gavaged with licorice root aqueous extractsolution (100, 200, and 300 mg/mLdistilled water, respectively) daily for three weeks. Licorice root aqueous extract solution (300 mg/mL distilled water) yielded notable reductions in liver, kidney enzymes, albumin, and AFP levels within the serum. Immunological tests, including immunohistochemical evaluations of caspase-3 and TNF-α expressions revealed a dose-dependent attenuation of apoptosis and inflammation with licorice intervention. This will provide a valuable perspective for agricultural practices future and paving the way for a more sustainable approach for using GBPs in animal agriculture industries.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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