Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets

• Anna Charalampidou,
• Thomas Nehls,
• Christian Meyners,
• Satish Gandhesiri,
• Sebastian Pomplun,
• Bradley L. Pentelute,
• Frederik Lermyte,
• Felix Hausch

Affiliations

Anna Charalampidou

Clemens-Schöpf-Institute, Department of Chemistry, Technical University of Darmstadt, Darmstadt, Germany

Thomas Nehls

Clemens-Schöpf-Institute, Department of Chemistry, Technical University of Darmstadt, Darmstadt, Germany

Christian Meyners

Clemens-Schöpf-Institute, Department of Chemistry, Technical University of Darmstadt, Darmstadt, Germany

Satish Gandhesiri

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

Sebastian Pomplun

Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands

Bradley L. Pentelute

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

Frederik Lermyte

Clemens-Schöpf-Institute, Department of Chemistry, Technical University of Darmstadt, Darmstadt, Germany

Felix Hausch

Clemens-Schöpf-Institute, Department of Chemistry, Technical University of Darmstadt, Darmstadt, Germany