Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens

Vikas Maurya; Raja Singh; Reman Kumar Singh; Stuti Pandey; Pooja Yadav; Palak Parashar; Rajni Gaind; Kshatresh Dutta Dubey; G. Naresh Patwari; Vibha Tandon

doi:10.1038/s42003-023-04412-1

Communications Biology (Feb 2023)

Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens

Vikas Maurya,
Raja Singh,
Reman Kumar Singh,
Stuti Pandey,
Pooja Yadav,
Palak Parashar,
Rajni Gaind,
Kshatresh Dutta Dubey,
G. Naresh Patwari,
Vibha Tandon

Affiliations

Vikas Maurya: Special Centre for Molecular Medicine, Jawaharlal Nehru University
Raja Singh: Special Centre for Molecular Medicine, Jawaharlal Nehru University
Reman Kumar Singh: Department of Chemistry, IIT Bombay, Powai
Stuti Pandey: Special Centre for Molecular Medicine, Jawaharlal Nehru University
Pooja Yadav: Special Centre for Molecular Medicine, Jawaharlal Nehru University
Palak Parashar: Special Centre for Molecular Medicine, Jawaharlal Nehru University
Rajni Gaind: Vardhaman Medical College Hospital, Safdarjung Hospital
Kshatresh Dutta Dubey: Department of Chemistry, School of Natural Sciences, Shiv Nadar University
G. Naresh Patwari: Department of Chemistry, IIT Bombay, Powai
Vibha Tandon: Special Centre for Molecular Medicine, Jawaharlal Nehru University

DOI: https://doi.org/10.1038/s42003-023-04412-1
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 20

Abstract

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Two potent inhibitors PPEF and BPVF of bacterial TopoIA enzymes function by impairing DNA binding and thus DNA cleavage and relaxation activities of bacterial topoisomerase I enzymes.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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