The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine

Hyoung-Soo Cho; Andrea Reboldi; Jason A. Hall; Leslie J. Berg

doi:10.1038/s41467-019-08699-9

Nature Communications (Feb 2019)

The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine

Hyoung-Soo Cho,
Andrea Reboldi,
Jason A. Hall,
Leslie J. Berg

Affiliations

Hyoung-Soo Cho: Department of Pathology, University of Massachusetts Medical School
Andrea Reboldi: Department of Pathology, University of Massachusetts Medical School
Jason A. Hall: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Leslie J. Berg: Department of Pathology, University of Massachusetts Medical School

DOI: https://doi.org/10.1038/s41467-019-08699-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Signals mediating tissue-specific control of immune cell fate and function remain largely uncharacterized. Here the authors uncover a requirement of ITK, a kinase mediating TCR signaling, for IL-2-dependent ILC2 cell survival specifically in the intestine.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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