MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

Wenyuan Wang; Tonis Org; Amélie Montel-Hagen; Peter D. Pioli; Dan Duan; Edo Israely; Daniel Malkin; Trent Su; Johanna Flach; Siavash K. Kurdistani; Robert H. Schiestl; Hanna K. A. Mikkola

doi:10.1038/ncomms12376

Nature Communications (Aug 2016)

MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

Wenyuan Wang,
Tonis Org,
Amélie Montel-Hagen,
Peter D. Pioli,
Dan Duan,
Edo Israely,
Daniel Malkin,
Trent Su,
Johanna Flach,
Siavash K. Kurdistani,
Robert H. Schiestl,
Hanna K. A. Mikkola

Affiliations

Wenyuan Wang: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles
Tonis Org: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles
Amélie Montel-Hagen: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles
Peter D. Pioli: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles
Dan Duan: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles
Edo Israely: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles
Daniel Malkin: Department of Molecular Toxicology, UCLA
Trent Su: Department of Biological Chemistry, David Geffen School of Medicine at UCLA
Johanna Flach: The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California San Francisco
Siavash K. Kurdistani: Department of Biological Chemistry, David Geffen School of Medicine at UCLA
Robert H. Schiestl: Department of Molecular Toxicology, UCLA
Hanna K. A. Mikkola: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles

DOI: https://doi.org/10.1038/ncomms12376
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable VDJ recombination.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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