Simple and Efficient Industrial Preparation of Various Trifluoromethyl Ketones and Derivatives

Abstract

Trifluoromethyl ketones are important tools in organic synthesis, useful especially for the production of complex fluorinated compounds. The preparation of ethyl 4,4,4-trifluoroacetoacetate and several attractive applications are described, as well as a new route leading to different fluorinated pyruvaldehydes and some examples of applications.

Keywords

• Building blocks
• Ethyl 4,4,4-trifluoroacetoacetate
• Fluorinated pyruvaldehydes
• Trifluoromethyl ketones