NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

René A. W. Frank; Noboru H. Komiyama; Tomás J. Ryan; Fei Zhu; Thomas J. O’Dell; Seth G. N. Grant

doi:10.1038/ncomms11264

Nature Communications (Apr 2016)

NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

René A. W. Frank,
Noboru H. Komiyama,
Tomás J. Ryan,
Fei Zhu,
Thomas J. O’Dell,
Seth G. N. Grant

Affiliations

René A. W. Frank: Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor’s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Noboru H. Komiyama: Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor’s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Tomás J. Ryan: Department of Biology, RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Fei Zhu: Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor’s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Thomas J. O’Dell: Department of Physiology, David Geffen School of Medicine and UCLA Integrative Center for Learning and Memory, University of California Los Angeles
Seth G. N. Grant: Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor’s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK

DOI: https://doi.org/10.1038/ncomms11264
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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NMDARs and MAGUK proteins are capable of forming higher-order protein assemblies, however their organisation in the intact brain is unclear. Here, Frank et al. identify mouse and human supercomplexes and discover their mechanism of assembly using genetic tagging and affinity purification.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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