P-105 PREVALENCE OF ANTIMITOCHONDRIAL ANTIBODIES IN PATIENTS WITH PRIMARY BILE CHOLANGITIS AND ITS OUTCOME IN LIVER TRANSPLANTATION

Abstract

Introduction: The presence of antimitochondrial antibodies has been described as a diagnostic criterion for primary biliary cholangitis. However, no studies have been established in the South American population to describe the prevalence of these antibodies in patients with biliary cholangitis. Furthermore, it would be important to assess the prevalence and identify whether the presence of these antibodies influences the recurrence of the disease. Objectives: To describe the prevalence of antimitochondrial antibodies in patients with cirrhosis due to primary biliary cholangitis undergoing liver transplantation.To assess the recurrence of primary biliary cholangitis and its relationship with the presence of antimitochondrial antibodies. Methods: It is a descriptive, cross-sectional observational study that evaluated transplant patients from 2006 to 2019 Results: Fifty patients with liver transplantation were identified with a greater representation of the female gender (47 cases, 94%), with an average age of 51 years (32-64), with only 1 patient being transplanted with severity according to the Child A scale (2%).), while 66% (33) of the transplanted patients had Child C severity at the time of surgery. A prevalence of 68% (34) of antimitochondrial antibodies was found in patients who underwent transplantation. Recurrence identified 5 years after transplantation was identified in only 10% (5) of the patients who underwent transplantation, and most of them with positive antimitochondrial antibodies (3 patients) Conclusion: The prevalence of antimitochondrial antibodies in primary biliary cholangitis is much lower when compared to several series in the literature, as well as the 5-year recurrence rate of the disease was quite low, which could suggest that the behavior of this disease in our Colombian population (mainly mestizo and indigenous) with a lower prevalence of these antibodies, it could influence the recurrence of the disease in transplant patients.