Biofilms and сhronic rhinosinusitis

Abstract

Introduction. A biofilm is a community of bacteria embedded in a matrix consisting of polysaccharides, nucleic acids, and proteins. Biofilms are resistant to antibiotics, antiseptics, and immune defense factors of the human body. Currently, the role of bacterial biofilms in the pathogenesis of chronic infections is known. There are a lot of articles confirming the detection of biofilms in diseases of the upper respiratory tract and ear: adenoiditis, recurrent and chronic otitis, laryngitis.Biofilms and Chronic Rhinosinusitis (CRS). Biofilms can play a significant role in prolonging inflammation in the paranasal sinuses. Biofilms are found in 76.7% of patients with CRS. This fact can serve as one of the explanations for the refractoriness of drug therapy and recurrent inflammations after surgical treatment.Methods for Controlling Biofilms. Is there a Way Out? As part of the strategy of removing biofilm, it is important to destroy its structure to planktonic forms, which will allow for the process of managing CRS progress. Antibiotic therapy alone is considered insufficient. Nasal irrigation can provide a violation of the biofilm integrity due to the mechanical destruction of its matrix and have a significant impact on the outcome of the disease. The nasal irrigation preparation containing isotonic sea water solution added with carbon dioxide (CO2-0.4%) has such an effect. In an experimental study, it was shown that 98% of the bacteria were non-viable when processing Staphylococus aureus biofilm.Conclusion. The impact on biofilms should be complex, including medication, physical means, irrigation of the nasal cavity.

Keywords

• chronic rhinosinusitis
• biofilms
• pharmacotherapy
• nasal irrigation
• nasal spray