Nature Communications (Apr 2019)
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis
- Yongjie Yang,
- Agatha A. van der Klaauw,
- Liangru Zhu,
- Tessa M. Cacciottolo,
- Yanlin He,
- Lukas K. J. Stadler,
- Chunmei Wang,
- Pingwen Xu,
- Kenji Saito,
- Antentor Hinton,
- Xiaofeng Yan,
- Julia M. Keogh,
- Elana Henning,
- Matthew C. Banton,
- Audrey E. Hendricks,
- Elena G. Bochukova,
- Vanisha Mistry,
- Katherine L. Lawler,
- Lan Liao,
- Jianming Xu,
- Stephen O’Rahilly,
- Qingchun Tong,
- UK10K Consortium,
- Inês Barroso,
- Bert W. O’Malley,
- I. Sadaf Farooqi,
- Yong Xu
Affiliations
- Yongjie Yang
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
- Agatha A. van der Klaauw
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Liangru Zhu
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
- Tessa M. Cacciottolo
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Yanlin He
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
- Lukas K. J. Stadler
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Chunmei Wang
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
- Pingwen Xu
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
- Kenji Saito
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
- Antentor Hinton
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
- Xiaofeng Yan
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
- Julia M. Keogh
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Elana Henning
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Matthew C. Banton
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Audrey E. Hendricks
- Wellcome Sanger Institute
- Elena G. Bochukova
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Vanisha Mistry
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Katherine L. Lawler
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Lan Liao
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Jianming Xu
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Stephen O’Rahilly
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Qingchun Tong
- Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- UK10K Consortium
- Inês Barroso
- Wellcome Sanger Institute
- Bert W. O’Malley
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- I. Sadaf Farooqi
- University of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Yong Xu
- Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza
- DOI
- https://doi.org/10.1038/s41467-019-08737-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obese individuals lead to loss of SRC-1 function.
