Effect of estradiol and cloprostenol combination therapy on expulsion of mummified fetus and subsequent fertility in four crossbred cows

Abstract

Four crossbred cows with mummified fetus were utilized for the study. The cows weresubjected togynecologicalexamination and based on the findings the cases were diagnosed asmummified fetus. The cows were treated with 2 mg estradiol valerate and 500 μg cloprostenoland were examined every 12 hr after 24 hr of the treatment for cervical dilatation and othersigns related to fetal expulsion. The time duration between treatment and starting of cervicaldilatation ranged from 48 to 58h (53.00 ± 2.08 hr). Complete dilatation of cervix was observedafter 70.00 ± 2.94 hr post treatment (Range = 64-76 hr). The mean fetalcrown-rump length(CRL) was 31.5 cm, which ranged from 27.5 to 38 cm. The number of cotyledons in pregnanthorn also showed wide variation (Range 24-38 numbers) with mean ± SE of 30.3 ± 3.07numbers. In the placenta of three animals irregular shaped large adventitious cotyledons wereobserved in the inter-cotyledonary areas. Out of the four animals treated, three animals wereconceived within three estrous cycles and one animal had cystic ovary in the next cycle and wasnot conceived even after four cycles. It was concluded that the estradiolandprostaglandin F2α(PGF2α)combinationtherapy was effective for expulsion of mummified fetus in crossbred cowswithout affecting much on future fertility.

Keywords

• Cloprostenol
• Crossbred cattle
• Estradiol
• Fertility
• Fetal mummification