Frontiers in Chemistry (Sep 2022)

Synthesis and characterization of new 1,4-dihydropyran derivatives by novel Ta-MOF nanostructures as reusable nanocatalyst with antimicrobial activity

  • Irfan Ahmad,
  • Saade Abdalkareem Jasim,
  • Ghulam Yasin,
  • Basim Al-Qargholi,
  • Ali Thaeer Hammid

DOI
https://doi.org/10.3389/fchem.2022.967111
Journal volume & issue
Vol. 10

Abstract

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Novel Ta- MOF was synthesized under mild conditions by ultrasound irradiations. The sample was characterized by SEM, FTIR, XRD, XPS, TG and BET technique. The final structures showed high physicho-chemical properties including narrow particle size distribution, homogenous morphology, high thermal stability and remarkable surface area. Ta- MOF synthesized in this study was used as a catalyst in the synthesis of 1,4-dihydropyran derivatives. The results proved that it has a high catalyst capability. Its advantages include high recyclability, less reaction time with higher efficiency and synthesis of new1,4-dihydropyran derivatives. In the following, antimicrobial activity including antifungal and antibacterial activity of Ta- MOF nanoparticles based on Minimum Inhibitory Concentration, Minimum Fungicidal Concentration and Minimum Bactericidal Concentration were evaluated. The synthesized Ta- MOF, in addition to high catalytic properties, showed high antimicrobial activity with MIC value between 16 and −256 μg/ml, and can be introduced as an agent against bacteria and fungi.

Keywords