CHEMICAL MODIFICATION OF SURGICAL SUTURE MATERIAL TO PREVENT ARTERIAL THROMBOSIS

Abstract

Suture material has significant influence on remote results of surgical intervention, and in particular, in reconstructive operations on heart and vessels. Despite the great choice of suture material in the market, there are no threads with directed antithrombotic effect. With the purpose of increasing thromboresistant properties of suture material, the most promising method is the application of biodegradable coating based on polyhydroxyalkanoate biopolymer and nonfractionated heparin by the method of chemical grafting. Antithrombotic coating of polypropylene thread is achieved through the creation of reactive intermediate layer. The study of grafting of heparin onto substrate by the methods of diffuse reflectance infrared spectroscopy and scanning electron microscopy showed uniform location and strong holding of heparin on the surface of the thread.

Keywords

• suture material
• thrombosis
• antithrombotic coating
• chemical grafting
• polymer
• heparin