Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions

Hongliang Tan; Song Guo; Ngoc-Duy Dinh; Rongcong Luo; Lin Jin; Chia-Hung Chen

doi:10.1038/s41467-017-00757-4

Nature Communications (Sep 2017)

Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions

Hongliang Tan,
Song Guo,
Ngoc-Duy Dinh,
Rongcong Luo,
Lin Jin,
Chia-Hung Chen

Affiliations

Hongliang Tan: Department of Biomedical Engineering, National University of Singapore
Song Guo: Department of Biomedical Engineering, National University of Singapore
Ngoc-Duy Dinh: Department of Biomedical Engineering, National University of Singapore
Rongcong Luo: Department of Biomedical Engineering, National University of Singapore
Lin Jin: Department of Biomedical Engineering, National University of Singapore
Chia-Hung Chen: Department of Biomedical Engineering, National University of Singapore

DOI: https://doi.org/10.1038/s41467-017-00757-4
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Cells contain isolated compartments where cascade enzymatic biochemical reactions occur to form essential biological products with high efficiency. Here the authors produce functional hydrogel particles with multiple compartments via microfluidics that contain spatially immobilized natural enzymes in distinct domains for one-pot, tandem reactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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