Nature Communications (Dec 2018)
Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells
- Song Chen,
- Lijun Fang,
- Wei Guo,
- Yushan Zhou,
- Gang Yu,
- Wenwen Li,
- Kui Dong,
- Jingru Liu,
- Yuechen Luo,
- Bing Wang,
- Zhonglong Li,
- Chunxiao Zhao,
- Zhina Sun,
- Yue Shen,
- Qibing Leng,
- Dongming Zhou,
- Zhongchao Han,
- Huifang Huang,
- He Ren,
- Guogang Xu,
- Xiaoming Feng
Affiliations
- Song Chen
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Lijun Fang
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Wei Guo
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Yushan Zhou
- Department of Respiration, The Second Affiliated Hospital of Nanchang University
- Gang Yu
- Department of Respiration, The Second Affiliated Hospital of Nanchang University
- Wenwen Li
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Kui Dong
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Jingru Liu
- Central Laboratory, The Union Hospital of Fujian Medical University
- Yuechen Luo
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Bing Wang
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Zhonglong Li
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Chunxiao Zhao
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Zhina Sun
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Yue Shen
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- Qibing Leng
- Institute Pasteur of Shanghai, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
- Dongming Zhou
- Institute Pasteur of Shanghai, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
- Zhongchao Han
- Beijing Health & Biotech Group Corp. Ltd.
- Huifang Huang
- Central Laboratory, The Union Hospital of Fujian Medical University
- He Ren
- Department of Pancreatic Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital
- Guogang Xu
- Nanlou Respiratory Department, Chinese PLA General Hospital
- Xiaoming Feng
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College
- DOI
- https://doi.org/10.1038/s41467-018-07545-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Regulatory T (Treg) cells are important for maintaining immune homeostasis by suppressing immune cell activation, but how the Treg cell pool is maintained is still unclear. Here the authors show that a kinase, Lkb1, operates in dendritic cells (DC) to inhibit Treg cell expansion and immunosuppression via mechanisms involving NF-kB/OX40L signalling.
