Nature Communications (Nov 2021)

Diet composition influences the metabolic benefits of short cycles of very low caloric intake

  • Alberto Diaz-Ruiz,
  • Tyler Rhinesmith,
  • Laura C. D. Pomatto-Watson,
  • Nathan L. Price,
  • Farzin Eshaghi,
  • Margaux R. Ehrlich,
  • Jacqueline M. Moats,
  • Melissa Carpenter,
  • Annamaria Rudderow,
  • Sebastian Brandhorst,
  • Julie A. Mattison,
  • Miguel A. Aon,
  • Michel Bernier,
  • Valter D. Longo,
  • Rafael de Cabo

DOI
https://doi.org/10.1038/s41467-021-26654-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Understanding the contribution of diet composition, calories and length of fasting in health maintenance is still challenging. Here the authors compare the effects of cycles of intermittent very low calorie intake achieved with a plant-based fasting mimicking diet or standard laboratory chow to provide insights into the role played by diet composition in mediating the metabolic benefits of short cycles of very low-calorie intake in mice.