Nature Communications (Oct 2020)
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
- Hui J. Wang,
- Chang Seok Lee,
- Rachel Sue Zhen Yee,
- Linda Groom,
- Inbar Friedman,
- Lyle Babcock,
- Dimitra K. Georgiou,
- Jin Hong,
- Amy D. Hanna,
- Joseph Recio,
- Jong Min Choi,
- Ting Chang,
- Nadia H. Agha,
- Jonathan Romero,
- Poonam Sarkar,
- Nicol Voermans,
- M. Waleed Gaber,
- Sung Yun Jung,
- Matthew L. Baker,
- Robia G. Pautler,
- Robert T. Dirksen,
- Sheila Riazi,
- Susan L. Hamilton
Affiliations
- Hui J. Wang
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Chang Seok Lee
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Rachel Sue Zhen Yee
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Linda Groom
- Department of Pharmacology and Physiology, University of Rochester Medical Center
- Inbar Friedman
- Department of Anesthesiology, University of Toronto
- Lyle Babcock
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Dimitra K. Georgiou
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Jin Hong
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Amy D. Hanna
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Joseph Recio
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Jong Min Choi
- Advance Technology Core, Mass Spectrometry Proteomics Core, Baylor College of Medicine
- Ting Chang
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Nadia H. Agha
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Jonathan Romero
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Poonam Sarkar
- Department of Pediatrics, Baylor College of Medicine
- Nicol Voermans
- Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Centre
- M. Waleed Gaber
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Sung Yun Jung
- Advance Technology Core, Mass Spectrometry Proteomics Core, Baylor College of Medicine
- Matthew L. Baker
- Advance Technology Core, Mass Spectrometry Proteomics Core, Baylor College of Medicine
- Robia G. Pautler
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Robert T. Dirksen
- Department of Pharmacology and Physiology, University of Rochester Medical Center
- Sheila Riazi
- Department of Anesthesiology, University of Toronto
- Susan L. Hamilton
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-18865-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS
