Human Vaccines & Immunotherapeutics (Mar 2021)

Leveraging on the genomics and immunopathology of SARS-CoV-2 for vaccines development: prospects and challenges

  • Idris Nasir Abdullahi,
  • Anthony Uchenna Emeribe,
  • Hafeez Aderinsayo Adekola,
  • Sharafudeen Dahiru Abubakar,
  • Amos Dangana,
  • Halima Ali Shuwa,
  • Sunday Theophilus Nwoba,
  • Jelili Olaide Mustapha,
  • Muyideen Titilope Haruna,
  • Kafayat Adepeju Olowookere,
  • Olawale Sunday Animasaun,
  • Charles Egede Ugwu,
  • Solomon Oloche Onoja,
  • Abdullahi Sani Gadama,
  • Musa Mohammed,
  • Isa Muhammad Daneji,
  • Dele Ohinoyi Amadu,
  • Peter Elisha Ghamba,
  • Nkechi Blessing Onukegbe,
  • Muhammad Sagir Shehu,
  • Chiladi Isomah,
  • Adamu Babayo,
  • Abdurrahman El-Fulaty Ahmad

DOI
https://doi.org/10.1080/21645515.2020.1812313
Journal volume & issue
Vol. 17, no. 3
pp. 620 – 637

Abstract

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The incidence and case-fatality rates (CFRs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the etiological agent for Coronavirus Disease 2019 (COVID-19), have been rising unabated. Even though the entire world has been implementing infection prevention and control measures, the pandemic continues to spread. It has been widely accepted that preventive vaccination strategies are the public health measures for countering this pandemic. This study critically reviews the latest scientific advancement in genomics, replication pattern, pathogenesis, and immunopathology of SARS-CoV-2 infection and how these concepts could be used in the development of vaccines. We also offer a detailed discussion on the anticipated potency, efficacy, safety, and pharmaco-economic issues that are and will be associated with candidate COVID-19 vaccines.

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